Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: Plasma bile acid comparisons between the hepatitis and control groups.

Article Snippet: Glycodeoxycholic acid (GDCA) was from Toronto Research Chemicals (Cat No: G641400; North York, ON, Canada).

Techniques: Clinical Proteomics, Control

Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: Specific bile acids show strong positive correlations with liver damage markers in the hepatitis and control groups. Pearson’s correlation coefficients of the 19 blood samples are visualized as heat maps, highlighting significant differences between the hepatitis and control groups. The correlation strength is classified as follows: 0.7 < |r| < 1.0 indicates a strong correlation. Total bilirubin (TBIL), direct bilirubin (DBIL), and aspartate transaminase (AST) were strongly and positively correlated with tauroursodeoxycholic acid (TUDCA) and glycochenodeoxycholic acid (GCDCA).

Article Snippet: Glycodeoxycholic acid (GDCA) was from Toronto Research Chemicals (Cat No: G641400; North York, ON, Canada).

Techniques: Control

Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: Bile acids show strong positive correlations with liver damage indicators in the hepatitis and control groups. Pearson’s correlation coefficients of the 19 blood samples are visualized as heat maps, illustrating significant relationships between bile acids, liver reserve, and liver fibrosis. The correlation strength is classified as follows: 0.7 < |r| < 1.0 indicates a strong correlation. Child–Pugh (CP), fibrosis-4 (FIB-4), and non-alcoholic fatty liver disease (NAFLD, also known as MASLD) fibrosis score (NFS) showed strong positive correlations with glycocholic acid (GCA). Similarly, the aspartate aminotransferase-to-platelet ratio index (APRI) was strongly correlated with taurocholic acid (TCA), taurochenodeoxycholic acid (TCDCA), and GCA. The model for end-stage liver disease (MELD) showed a strong positive correlation with glycochenodeoxycholic acid (GCDCA).

Article Snippet: Glycodeoxycholic acid (GDCA) was from Toronto Research Chemicals (Cat No: G641400; North York, ON, Canada).

Techniques: Control

Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: A total of 8 bile acids with under the curve (AUC) value >0.700 are shown. The AUC values for ursodeoxycholic acid (UDCA), chenodeoxycholic acid (CDCA), taurocholic acid (TCA), tauroursodeoxycholic acid (TUDCA), taurochenodeoxycholic acid (TCDCA), glycoursodeoxycholic acid (GUDCA), glycochenodeoxycholic acid (GCDCA), and glycocholic acid (GCA) were 0.900, 0.811, 0,922, 0.950, 0.906, 0.928, 0.889 and 0.944, respectively. The cutoff values were as follows: UDCA was 21.02 pmol/mL, CDCA was 56.77 pmol/mL, TCA was 187.49 pmol/mL, TUDCA was 22.64 pmol/mL, TCDCA was 643.25 pmol/mL, GUDCA was 72.71 pmol/mL, GCDCA was 1647.77 pmol/mL, and GCA was 619.79 pmol/mL.

Article Snippet: Glycodeoxycholic acid (GDCA) was from Toronto Research Chemicals (Cat No: G641400; North York, ON, Canada).

Techniques: